https://live.paloaltonetworks.com/t5/cortex-xdr-discussions/cortex-xdr-and-microsoft-defender-coexistence-and-performance/m-p/1257952#M9409 <P><SPAN>Hello Cortex XDR Community,</SPAN><BR /><BR /><BR />We recently&nbsp; were asked to have official guidance regarding the coexistence of Cortex XDR Agent and Microsoft Defender on Windows endpoints.<BR /><BR /></P> <P>My questions to the community and experts is:<BR /><BR /></P> <P>- Is the coexistence of Cortex XDR and Microsoft Defender Antivirus officially supported?<BR /><BR /></P> <P>- Is the coexistence of Cortex XDR and Microsoft Defender for Endpoint (MDE) supported?<BR /><BR /></P> <P>-When Cortex XDR is installed, does it automatically disable Microsoft Defender Antivirus, or can both solutions remain active simultaneously?</P> <P><BR />- Are there any known limitations, performance impacts, or best practices when running both products on the same endpoint?</P> <P><BR />- Is there any official documentation or configuration guide describing the recommended deployment model for organizations using both Cortex XDR and Microsoft Defender technologies?<BR /><BR />Thank you</P> Thu, 02 Jul 2026 15:44:10 GMT omonroy502642 2026-07-02T15:44:10Z https://live.paloaltonetworks.com/t5/cortex-xdr-discussions/cortex-xdr-and-microsoft-defender-coexistence-and-performance/m-p/1257952#M9409 <P><SPAN>Hello Cortex XDR Community,</SPAN><BR /><BR /><BR />We recently&nbsp; were asked to have official guidance regarding the coexistence of Cortex XDR Agent and Microsoft Defender on Windows endpoints.<BR /><BR /></P> <P>My questions to the community and experts is:<BR /><BR /></P> <P>- Is the coexistence of Cortex XDR and Microsoft Defender Antivirus officially supported?<BR /><BR /></P> <P>- Is the coexistence of Cortex XDR and Microsoft Defender for Endpoint (MDE) supported?<BR /><BR /></P> <P>-When Cortex XDR is installed, does it automatically disable Microsoft Defender Antivirus, or can both solutions remain active simultaneously?</P> <P><BR />- Are there any known limitations, performance impacts, or best practices when running both products on the same endpoint?</P> <P><BR />- Is there any official documentation or configuration guide describing the recommended deployment model for organizations using both Cortex XDR and Microsoft Defender technologies?<BR /><BR />Thank you</P> Thu, 02 Jul 2026 15:44:10 GMT https://live.paloaltonetworks.com/t5/cortex-xdr-discussions/cortex-xdr-and-microsoft-defender-coexistence-and-performance/m-p/1257952#M9409 omonroy502642 2026-07-02T15:44:10Z