Just to clarify, what appears to have resolved the issue was installing it again with only GlobalProtect checked in the install. Leaving GlobalProtect System Extensions unchecked. The GlobalProtect app 5.1.4 running on macOS Catalina 10.15.4 or later does not use kernel extensions and will use system extensions. The GlobalProtect app 5.1.4 running on macOS Catalina 10.15.4 or later will not use the kernel extensions ( com.paloaltonetworks.kext.pangpd ) and instead will use any of the available utun interfaces provided by macOS as the virtual adapter. If you are upgrading from an earlier release to the GlobalProtect app 5.1.4 running on macOS Catalina 10.15.4 or later, kernel extensions are no longer needed. After the upgrade, the System Extension Blocked notification message displays on the GlobalProtect app, prompting users to enable and allow the system extensions in macOS that was blocked from loading. By default, the app will not install system extensions and the same default settings are applied. https://docs.paloaltonetworks.com/globalprotect/5-1/globalprotect-app-user-guide/globalprotect-app-for-mac/download-and-install-the-globalprotect-app-for-mac.html
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