We had the same issue, with ADUC and a couple other apps we had. We dug into our DNS, and found we did not have a reverse lookup for the IP scopes of GlobalProtect IPs. Once we added those and they started to populate, it was better. It is still not as fast as being in the LAN, but it is usable now. Takes 1-2 mins for it to come up, and is pretty responsive after that. Thought I would share! BTW we are using Win10 with a mix of 1803 and 1903 (that is a long story), with GP 5.0.5
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