1) you said "ou would likely have 2 sets of vwires to handle each 'channel',"
asymmetric routing has packets egressing via one path and returning via another. It is paramount that you get the firewall placed so that it is able to see both flows of data and can inspect the entire transaction, else the firewall is rendered useless
this could be achieved by placing a vwire in each path, having all zones matched up, to create a virtual 'double whammy' vwire
2) on a single chassis you may need to set up policy based forwarding with symmetric return enabled
when your firewall needs to perform routing and is receiving packets for the same conversation on different interfaces, things can get messy real quick. we have a feature called Policy Based Forwarding which allows you to bypass normal routing and force packets out of a different interface, and in this feature there's an option called symmetric return which 'fixes' asymmetry by forcing returning packets out of an interface that is not supposed to be used if you would follow regular routing
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