Which PANOS are you running? Because even if 5.x is supposed to somewhat fix the dependency hell (inspired by the Microsoft dll hell? 😉 it seems that not all dependencies are being taken care of by the 5.x release. Another issue with this "magic" auto dependency in the background is for how many packets should it allow traffic before the auto depedent appid is being blocked? For example smtp for the case of gmail should only be valid if the domain is .google.com (and whatever other domains google uses nowadays). It would be really bad if the auto depedency suddently, silently, allows any smtp to the rest of the world while you as an admin think you have only allowed gmail as appid... (sure, a workaround might be to add custom urldb that only allows this rule if the http host request matches but still).
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