Hello I am curious if there is a way to block hardcoded IP's containing applications? So I would allow downloads when there is a domain name but not allow the download when it is a IP.
One of the biggest limitations I can see with this is you wouldn't really hit the 7 byte limitation of a custom application signature or a custom vulnerability signature to do this properly. URL Filtering by itself to the best of my knowledge also doesn't allow Regular Expression so you couldn't use that directly either.
Usually (not always) IPs fall into Unknown URL category.
You could try adding rule above your regular rule:
zone - trust > untrust
url category - unknown
file blocking profile - block any unwanted file
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