I highly recommend a support case. Grab pcaps of the traffic and a techsupport file to attach to the chase to make things go quicker. I am also seeing this behavior on one system. Our change was a code upgrade to 8.0.9. We are waiting for the results of our case and I will post if its relevant to this one.
It doesn't sound you have enough investigation to exclude problems with adjacent devices...
- Have you done a packet capture when the issue occur?
- Can you confirm that the packets are coming from the right interface/zone?
- Have you compare packet captures when the issue occurs and when there is not issues?
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