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Again, it really depends on what you are trying to do. If it's using ISE for TACAS and authenticate via AD then CHAP will not work. I have provided chart above in this article why it will not work.

If you are going to create local accounts on ISE then CHAP will work fine.
A lot of folks if you haven't noticed yet in their TACACS articles are using CHAP, yes, but they create accounts locally. No one mentions that AD for authentication using CHAP is not supported in ISE.

Anatoliy Pshenichnykh
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