Had the same issues with 8.1.0 and went back to 8.0.8.
We experienced slow/non-working domain logons and SMB/CIFS/DFS Shares.
If I ran "show session all filter state discard application ms-ds-smbv3" I had lots of sessions discarded. If I looked in detail on one of those sessions with show session id [session-id] I could see that they were discarded due to "resources-unavailable".
Some users report that 'Application Override' might be a way forward until the issue is fixed.
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