Our users were running for some time using a self-sgined certificate with few errors and issues.
I was trying to install a wildcard certificate to replace the one in use, but no matter what I do, I ended up with the error message "The network connection is unreachable or the portal is unresponsive. Check the network connection and reconnect.
The same certificate with similar configuration is working just fine on other firewalls. However, other firewalls didn't had a previous configuration with self-signed certificate.
No need to say, there is nothing in the Monitor\globalprotect , not even a prelogin entry. It's just like the agent itself didn't like the new certificate on the firewall. Even worse, GP log shows nothing useful.
I tried the connection from three different machines running Windows and mac with the same exact result.
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