Hi @Metgatz ,
This is something that you can easily try out so I went ahead and tested it for you.
I use my local user configured with AuthProfile - The user was locked out after reaching the number of Failed Attempts which was configured on the AutProfile, totally ignoring my global lock out settings (which was configured with a lower number).
Tested on LAB environment running PAN-OS 10.1.x
Hope this helps,