You could setup it this way if you still want to keep the VWIRE (just an example): VSYS1: int0, int1 VSYS2: int2, int3 and then in the switch before and after your PAN split up which VLAN will be sent through which VSYS like so: internal-switch (VLAN10) gi0/1 -> PAN int0 internal-switch (VLAN20) gi0/2 -> PAN int2 external-switch (VLAN10) gi0/1 -> PAN int1 external-switch (VLAN20) gi0/2 -> PAN int3 But I would recommend you switch to a layer3 type deployment. Using VWIRE (in my opinion) is more of a IDP/IPS scenario rather than having the PAN taking more decisions regarding what the nexthop should be and stuff like that. You can still use VSYS with layer3 deployment, actually it will in some way better utilize the interfaces available (comparing to just use a single interface for all traffic connected to the uplink) and it will also minimize rules needed in each VSYS if you for example split up so one VSYS will be for webbrowsing while the other VSYS will be used for handling your regular production based traffic like email, DMZ etc.
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