Hello @Shahwaz_Md ,
Trend Micro Deep Security is mostly an HIPS solution which works on Real time basis where Cortex is an XDR Solution which prevents Zero Day threats, Ransomware and has mobile protection. Both the solutions has their own capabilities. Cortex XDR has host firewall and not an Intrusion prevention system. Regarding Web Reputation , you have to add URL as an IOC to block the access , however Deep Security has much more capability in terms of it. Hence, would suggest you to evaluate both the products and use the required features as per your need.
Hope this helps!
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Ashutosh Patil