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Hi @paul.leach 

Thank you for writing to live community!

Based on your above observation it seems to be application conflict/compatibility issues with one of the protection module in your specific case because per your update edge works fine post XDR agent removal.

Here is the guide that can be used as a starting point for determining the source of the problem. You may start with Step 2 as shared in the guide "Verify if the issue is related to the Exploit protection profile. " 

https://knowledgebase.paloaltonetworks.com/KCSArticleDetail?id=kA14u0000004NPrCAM
Once you identify module causing this you may submit the logs with our TAC for investigation or you may directly open support case by collecting and attaching the logs needed for support investigation.

Please mark the response as "Accept as Solution" if it answers your query.

Hope this helps!

Thanks